ABSTRACT:
Ethanolic extract of Euphorbia hirta where evaluated for their carbohydrate enzyme inhibition, it is the key indicator for anti-diabetic potential. The inhibitory activity of EEEH against carbohydrate-digesting enzymes was evaluated and compared with the standard drug acarbose. EEEH exhibited moderate α-amylase inhibitory activity, with an IC₅₀ value of 1.16 mg/mL, indicating measurable enzyme suppression. In comparison, acarbose demonstrated significantly stronger inhibition, as reflected by a lower IC₅₀ value of 0.42 mg/mL. The inhibitory activity of EEEH against α-glucosidase was evaluated and compared with the standard drug acarbose. EEEH exhibited moderate α-glucosidase inhibitory activity, with an IC₅₀ value of 1.21 mg/mL, indicating appreciable enzyme suppression. In contrast, acarbose showed stronger inhibitory potential, as evidenced by a lower IC₅₀ value of 0.44 mg/mL.
Cite this article:
Dr. Sundhararajan R, L K. Dhivya*, Mohan. N, Paul Christober. M, Surya Prakash. S, Tamil selvan. Evaluation of In-vitro Anti-diabetic activity in Ethanolic Stem Extract of Euphobia hirta. IJRPAS, February 2026; 5(2): 88-92.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2026.5207
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