International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Implantable Drug Delivery Systems: A Comprehensive Review with Recent Advancements

Author(s): Akanksha Thakur1, Deepak Prashar*2, Pallavi Sharma3, Shilpa4, Dixit Panwar5

Email(s): 1prashardeepak99@yahoo.in

Address:

    Department of Pharmacy, LR Institute of Pharmacy, Jabli-Kyar, Solan HP-India.

Published In:   Volume - 5,      Issue - 3,     Year - 2026

DOI: https://doi.org/10.71431/IJRPAS.2026.5305  

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ABSTRACT:
Implantable drug delivery systems (IDDS) represent a transformative approach in pharmacotherapy, offering localized, sustained, and patient-compliant drug administration over extended periods. These sophisticated devices bypass the limitations of conventional oral and parenteral formulations by maintaining consistent therapeutic drug concentrations, improving bioavailability, and minimizing systemic adverse effects. This review comprehensively examines the classification, mechanisms, biomaterials, and clinical applications of IDDS, while highlighting major technological advancements achieved between 2021 and 2025. Special attention is given to stimuli-responsive smart implants, biodegradable polymer systems, nanotechnology-integrated devices, wirelessly controlled platforms, and bio-electronic medicines. Regulatory frameworks governing approval and commercialization are discussed, along with persistent challenges such as foreign body response, device fouling, drug stability, and retrieval logistics. The review underscores the enormous potential of IDDS in managing chronic conditions including diabetes, cancer, cardiovascular disease, neurological disorders, and hormonal imbalances, while acknowledging the translational hurdles that must be overcome for broader clinical adoption.

Keywords:

Cite this article:
Akanksha Thakur, Deepak Prashar*, Pallavi Sharma, Shilpa, Dixit Panwar. Implantable Drug Delivery Systems: A Comprehensive Review with Recent Advancements. IJRPAS, March 2026; 5(3): 55-69.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2026.5305


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