International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Assessment of Amplitude of Accommodation (A.A) Among HIV Subjects Taking Antiretroviral Drugs (ARV)

Author(s): Ohaegbule Eberechukwu John Uzoma1, Nwakaego Ikoro2, Young Azuamah3, Victoria Nkemka4

Email(s): 1johnpimmac@gmail.com

Address:

    Department of Optometry, Federal University of Technology Owerri, Nigeria

Published In:   Volume - 5,      Issue - 2,     Year - 2026

DOI: https://doi.org/10.71431/IJRPAS.2026.5204  

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ABSTRACT:
The eye is a common site of manifestation of systemic diseases, particularly in immunocompromised individuals. Human immunodeficiency Virus (HIV) infection and its treatment with antiretroviral drugs (ARVs) have been associated with ocular changes, including variations in amplitude of accommodation (A.A). While antiretroviral therapy (ART) has significantly improved survival, its long-term ocular effects remain underexplored. The study assessed the amplitude of accommodation (A.A) among HIV subjects taking antiretroviral drugs (ARVs). Immunocompromised subjects on first-line ARV (ARV1) and those on second-line ARV (ARV2) show no difference in A.A. Their A.A is more likely to be affected by age, systemic health status and ocular comorbidities than the ARV they are taking. ART itself does not appear to exert a direct pharmacological effect on the accommodative apparatus of the eye. The mean amplitude of accommodation was 7.62D among subjects on first-line ARV and 9.61D among those on second-line ARV, with no significant difference between the two groups and with P value = 1.00. There was no difference in A.A between immunocompromised subjects taking ARV1 and ARV2.

Keywords:

Cite this article:
Ohaegbule Eberechukwu John Uzoma, Nwakaego Ikoro, Young Azuamah, Victoria Nkemka. Assessment of Amplitude of Accommodation (A.A) Among HIV Subjects Taking Antiretroviral Drugs (ARV). IJRPAS, February 2026; 5(2): 35-47.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2026.5204


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