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Author(s): Rahil Salim Meman1*1, Furkhan Khan Younus Khan22

Email(s): 1memon.rahil99@gmail.com

Address:

    1 Department of Pharmaceutics, Ismail Mehta College of Pharmacy, Ambad. 2 Department of Pharmacology, Ismail Mehta College of Pharmacy, Ambad.

Published In:   Volume - 5,      Issue - 2,     Year - 2026

DOI: https://doi.org/10.71431/IJRPAS.2026.5202  

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ABSTRACT:
The scarcity of compatible blood for transfusion remains a critical challenge in emergency medicine, particularly in trauma, surgical, and battlefield scenarios[1]. Plastic blood, or synthetic blood substitutes, represent a transformative advancement in addressing this global shortage. These engineered solutions utilize hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon products to provide immediate oxygen delivery without requiring blood typing or compatibility testing[2]. This research paper examines the current state of plastic blood technology, including its composition, mechanisms of action, clinical applications, advantages over traditional blood transfusions, and ongoing challenges in achieving widespread clinical implementation.

Cite this article:
Rahil Salim Meman, Furkhan Khan Younus Khan. Plastic Blood: Synthetic Blood Substitutes in Emergency Medicine for Patient Transfusion. IJRPAS, February 2026; 5(2): 11-19.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2026.5202


1.    NHLBI. (2024). Potential game-changer for emergency medicine: Synthetic platelets. National Institutes of Health. https://www.nhlbi.nih.gov/news/2024/potential-game-changer-emergency-medicine-synthetic-platelets

2.    NIH/PMC. (2024). Artificial blood for therapeutic and laboratory usage. PubMed Central, 11427025. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC11427025/

3.    NIH/PMC. (1999). Blood substitutes: Haemoglobin therapeutics in clinical use. Transfusion Medicine Reviews, 13(4), 1-25. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC137240/

4.    NIH/PMC. (2020). Artificial blood: The history and current perspectives of hemoglobin-based oxygen carriers. Frontiers in Medicine, 7, 86. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC7086064/

5.    Science Magazine. (2024, July 2). The ultimate blood substitute? The U.S. military is betting $46 million. Science, 385(6), 245-248. https://www.science.org/content/article/ultimate-blood-substitute-us-military-betting-46-million

6.    NPR. (2025, July 24). Scientists are developing artificial blood that could save lives. Shots - Health News. https://www.npr.org/sections/shots-health-news/2025/07/24/nx-s1-5477632/artificial-blood-hemorrhage-emergency-medicine

7.    NIH/PMC. (2018). Artificial blood: A futuristic dimension of modern day transfusion medicine. Journal of Laboratory Medicine, 42(6), 234-245. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC6864588/

8.    ASH Clinical News. (2025, February 19). Banking on artificial blood. American Society of Hematology Clinical News. https://ashpublications.org/ashclinicalnews/news/8465/Banking-on-Artificial-Blood

9.    Al Jazeera. (2025, March 8). How close are scientists to producing artificial blood? Retrieved from https://www.aljazeera.com/news/2025/3/8/how-close-are-scientists-to-producing-artificial-blood

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