The present investigation concludes that Mimusops elengi flower extract is a suitable and effective biological reducing and stabilizing agent for the green synthesis of zinc oxide nanoparticles. UV–Visible spectroscopy confirmed successful nanoparticle formation with good stability and uniformity. The synthesized Zinc oxide nanoparticles exhibited significant in vitro anti-diabetic activity by effectively inhibiting α-amylase and β-glucosidase enzymes in a concentration-dependent manner, with activity comparable to the standard drug acarbose. These findings suggest that Mimusops elengi flower extract-mediated Zinc oxide nanoparticles possess strong potential as safe, eco-friendly, and effective anti-diabetic nanotherapeutic agents. Further in vivo studies and toxicity evaluations are warranted to validate their clinical applicability and therapeutic usefulness in diabetes management.

ACKNOWLEDGEMENT

The faculty team of Mohammed Sathak AJ College of Pharmacy is acknowledged by the authors for their assistance in this study.

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