International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Design and Optimization of Extended-Release Mini-Tablets of Metoprolol Succinate Using Okra Stalk Powder and HPMC K100 M as Release Modifiers

Author(s): Gayatri C. Pawar11, Tanvirahmad J. Shaikh12, Harshal D. Mahajan13, Rajendra D. Wagh24

Email(s): 1gayatripawar5999@gmail.com

Address:

    1. Department of Pharmaceutics, DCS’s A. R. A. College of Pharmacy, Nagaon, Dhule. 2. Department of Pharmaceutical Chemistry, DCS’s A. R. A. College of Pharmacy, Nagaon, Dhule.

Published In:   Volume - 4,      Issue - 6,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4617  

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ABSTRACT:
The present study focuses on the design and optimization of extended-release (ER) mini-tablets of Metoprolol Succinate using Okra stalk powder as a natural release modifier and HPMC K100 M as a synthetic matrix polymer. A 3² factorial design was applied to evaluate the impact of two independent variables—concentration of Okra stalk powder (X₁) and HPMC K100 M (X₂)—on two response parameters: percentage drug release at 1 hour (Y₁) and at 12 hours (Y₂). Nine formulations (F1–F9) were prepared by direct compression and evaluated for pre-compression and post-compression characteristics. Results confirmed acceptable flowability, uniformity, hardness, and friability. The optimized batch (F6) demonstrated sustained release and acceptable physical parameters. This study concludes that Okra stalk powder is a viable natural polymer for sustained-release matrix formulations, especially in mini-tablet systems.

Keywords:

Cite this article:
Gayatri C. Pawar, Tanvirahmad J. Shaikh1, Harshal D. Mahajan1, Rajendra D. Wagh2. Design and Optimization of Extended-Release Mini-Tablets of Metoprolol Succinate Using Okra Stalk Powder and HPMC K100 M as Release Modifiers. IJRPAS, June 2025; 4 (6): 154-162.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4617


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