International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Neuroprotective Potential of Fenugreek and Black Cumin in Alzheimer’s Disease: A Comprehensive Review

Author(s): Vishakha Tyagi11, Yashvardhan Vats12, Qurratul Ain13, Vipin Kumar14, Shabnam Ain1* Raj Kumar Garg2 and Sneha Pandey15

Email(s): 1shabnam.ain@sanskar.org

Address:

    1Sanskar College of Pharmacy and Research, Ghaziabad, U.P, India 2 K. D. Medical College, Mathura, U.P, India

Published In:   Volume - 4,      Issue - 5,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4504  

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ABSTRACT:
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder marked by progressive cognitive decline, memory impairment, and behavioural disturbances. Despite extensive research efforts, current therapeutic options remain limited, and there is a pressing need for novel interventions that can slow or halt disease progression. Recently, attention has turned towards natural compounds with potential neuroprotective effects. Fenugreek (Trigonella foenum-graecum) and black cumin (Nigella sativa) are two such herbs that have been historically used in traditional medicine for a variety of health conditions. This review examines the current scientific literature on the neuroprotective potential of Fenugreek and Nigella sativa, focusing on their anti-inflammatory, antioxidant, and neurogenic properties in the context of Alzheimer’s disease. The review also explores the possibility of these herbs being incorporated into integrative therapeutic strategies for AD, alongside conventional treatments, and highlights areas for future research.

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Cite this article:
Vishakha Tyagi, Yashvardhan Vats, Qurratul Ain, Vipin Kumar, Shabnam Ain,Raj Kumar Garg and Sneha Pandey.Neuroprotective Potential of Fenugreek and Black Cumin in Alzheimer’s Disease: A Comprehensive Review. IJRPAS, May 2025; 4 (5): 36-45.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4504


1.      Garg, Tarun Gupta, Ankur Bala, Rajni, Sharma, Poonam. (2013). Development and evaluation of herbal deodorant formulations. Journal of Cosmetic Science, 64(4), 351–360.

2.       Pankaj Sharma & Anjali Thakur (2017). Herbal cosmetics: A safe alternative to synthetic deodorants. Journal of Ayurveda and Integrative Medicine, 8(3), 187–194.

3.      Rani, Sunita, Meena, Kapil, Bhardwaj, Ritika, & Soni, Sanjay. (2018). Formulation and evaluation of a herbal deodorant stick using natural essential oils. International Journal of Pharmaceutical Sciences and Research, 9(5), 1894–1899.

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5.       Neha Chauhan, Nitin  Kaushik, Parul, & Yadav Harsh. (2020). Herbal cosmetics: A review on formulations and evaluation. Journal of Cosmetic Dermatology, 19(2), 343–350.

6.       Swati Saini, Vikas Bansal, Sunita Kumar, Anil Agarwal (2015). Antimicrobial and deodorizing properties of essential oils in herbal deodorant formulations. International Journal of Cosmetic Science, 37(5), 467–473.

7.      Dinesh, Deepak Verma, Ritu Patel, Rakesh Saxena, Shraddha. (2016). Evaluation of herbal formulations as natural deodorants. Indian Journal of Pharmaceutical Education and Research, 50(3), 503–509.

8.      Vikram Srivastava, Neelam Tiwari, Anamika Mishra, Ramesh Kumar (2018). Essential oils as a natural alternative for deodorant formulations: A review. Journal of Essential Oil Research, 30 (1), 1–15.

9.      Shalini Singh, Priya Jain (2014). Development of herbal deodorant with antimicrobial properties. Asian Journal of Pharmaceutical Research and Development, 2(2), 98–103.

10.  Saurabh Mishra, Sangeeta Kumari (2021). Sustainable and eco-friendly herbal deodorant formulation: Development and evaluation. International Journal of Green Pharmacy, 15(1), 25–32

11.  Sneha Pandey, Vipin Kumar, Shabnam Ain, Qurratul Ain, Babita Kumar, Nidhi Ruhela, Bhuvnesh. (2025). Alzheimer’s disease: An Overview. International Journal of Research in Pharmacy and Allied Science, 4(2), 13-32.

12.  Sneha Pandey, Vipin Kumar, Shabnam Ain, Qurratul Ain, Bhuvnesh, Nidhi Ruhela, Chhavi Nagar, Babita Kumar. (2025). Impact of Heavy Metals on Respiratory Disease. International Journal of Research in Pharmacy and Allied Science, 4(3), 1-12.

13.  Mehtab Ali, Shabnam Ain, Babita Kumar, Qurratul Ain. (2022). Development and evaluation of eugenol-based gel formulation for analgesic and anti-inflammatory action. Annals of Phytomedicine, 11(1): 338-345.

14.  Parvesh Kumar Dhama, Shabnam Ain, Babita Kumar, Qurratul Ain. (2022). Development and evaluation of topical ointment formulation containing gallic acid as an active pharmaceutical ingredient against bacterial infection and oxidative damage. Annals of Phytomedicine, 11(11): 439-449.

15.  Shabnam Ain, Gaurav Mishra, Babita Kumar, Qurratul Ain, Raj Kumar Garg. (2022). Antidiabetic Potential of Developed Solid Lipid Nanoparticles Loaded with Quercetin: in-vitro and in-silico Studies. Annals of Phytomedicine, 11(2): 1-11.

16.  Zulekha Ali, Shabnam Ain, Shalini Sharma, Qurratul Ain, Babita Kumar. (2025). Recent Advances in Osteoarthritis: Pathophysiology, Diagnosis, and Therapeutic Strategies. Cuestiones de Fisioterapia, 54 (2), 787-811

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