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Author(s): Nidhi Ruhela1, Vipin Kumar2, Shabnam Ain*3, Qurratul Ain4, Sneha Pandey5, Bhuvnesh6, Vishakha Tyagi7, Ajeet8, Babita Kumar9

Email(s): 1shabnam.ain@sanskar.org, 2

Address:

    Sanskar College of Pharmacy and Research, Ghaziabad, Uttar Pradesh 201302, India

Published In:   Volume - 4,      Issue - 5,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4502  

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ABSTRACT:
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by motor symptoms and dopaminergic neuronal loss. Conventional dopamine replacement therapies, such as levodopa, alleviate symptoms but have limitations and adverse effects. Fava beans (Vicia faba) have emerged as a promising complementary therapy for PD due to their high L-DOPA content. Clinical evidence suggests that fava beans may reduce PD symptoms, particularly in patients with mild to moderate disease. Fava bean extracts or supplements have improved motor function, reduced tremors, and enhanced quality of life. Potential neuroprotective effects may slow disease progression. While fava beans offer therapeutic promise, potential benefits and risks must be considered. Interactions with conventional medications and exacerbation of existing conditions require careful evaluation. Further research is necessary to determine optimal dosing regimens, efficacy, and safety. Fava beans may provide a valuable adjunctive treatment for PD, enhancing symptom alleviation and quality of life.

Cite this article:
Nidhi Ruhela, Vipin Kumar, Shabnam Ain, Qurratul Ain, Sneha Pandey, Bhuvnesh, Vishakha Tyagi, Ajeet, Babita Kumar. Fava beans: An Ancient Tool to Manage Parkinson’s Disease. IJRPAS, May 2025; 4 (5): 13-25.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4502


1.      You H, Mariani LL, Mangone G, Le Febvre de Nailly D, Charbonnier-Beaupel F, Corvol JC. 2018, Molecular basis of dopamine replacement therapy and its side effects in Parkinson’s disease. Cell Tissue Res.; 373 (1):111-135. Doi: 10.1007/s00441-018-2813-2.

2.      Parkinson’s Disease Risk Factors and Causes. Johns Hopkins Medicine. Available from: https://www.hopkinsmedicine.org/health/conditions-and-diseases/parkinsons-disease/parkinsons-disease-risk-factors-and-causes.

3.      Jankovic J, Aguilar G L. 2008, Current approaches to the treatment of Parkinson’s disease;4(4):743-757. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC2536542/.

4.      Randhir R , Vattem D, Shetty K. 2004, Solid-state bioconversion of fava bean by Rhizopusoligosporus for enrichment of phenolic antioxidants and l-DOPA; 5(2):235-244. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1466856404000098.

5.      Neill A, Gut health, Parkinson’s and eating legumes. Parkinson’s diet. 2018. Available from: https://parkinsondiet.com/promote-gut-health-by-eating-legumes/.

6.      FatemehEtemadi, Masoud Hashemi, Reena Randhir, Omid Zand Vakili, Ali Ebadi. 2018, Accumulation of l-DOPA in various organs of Fava bean and influence of drought, nitrogen stress, and processing methods on l-DOPA yield, The Crop Journal;6(4):426-434 Available from: https://www.sciencedirect.com/science/article/pii/S2214514118300023.

7.      Zhou ZD, Ling Xiao Yi LX, Tan EK. 2023, Role of dopamine in the pathophysiology of Parkinson’s disease. Available from: https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-023-00378-6.

8.      Parkinson’s disease: Causes, Symptoms, and Treatment. National Institutes of Health. Content reviewed 2022. Available from: https://www.nia.nih.gov/health/parkinsons-disease/parkinsons-disease-causes-symptoms-and-treatments.

9.      Zhou, Z.D., Yi, L.X., Wang, D.Q. et al. 2023, Role of dopamine in the pathophysiology of Parkinson’s disease. Trans Neurodegener 12;44. Available from: https://doi.org/10.1186/s40035-023-00378-6.

10.  Parkinson’s disease. Mayoclinic. 2024. Available from: https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/symptoms-causes/syc-20376055.

11.  Parkinson’s Disease. Cleveland Clinic. Last reviewed on 2022. Available from: https://my.clevelandclinic.org/health/diseases/8525-parkinsons-disease-an-overview.

12.  Overview-Parkinson’s disease. NHS. Last reviewed 2022, next reviewed November 3,2025. Available from: https://www.nhs.uk/conditions/parkinsons-disease/.

13.  FahnS. 2006, Levodopa in the treatment of Parkinson’s disease. Chapter Oxidative Stress and Neuroprotection. Neural Transmission. Supplementa;77, Pp 1-15. Available from: https://link.springer.com/chapter/10.1007/978-3-211-33328-0_1.

14.  Herrera PBF, Cabrera BEH, Ayala ALM, Zamilpa A, Adriana , Alvarado AD. 2023, Content and Yield of L-DOPA and Bioactive Compounds of Broad Bean Plants: Antioxidant and Anti-Inflammatory Activity In Vitro; 12 (23): 3918. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10708485/.

15.  Ryu1 J, Kim DJ, Lee1 MK, Kim JM, Hong MJ, Kang KY, Eom SH, et, al. 2017, Fatty Acid Composition, Isoflavone and L-3,4-dihydroxyphenylalanine (L-dopa) Contents in Different Parts of Fava Bean  (Vicia fava) Genotypes. Plant Breeding and Biotechnology; 5:314-324. Available from: https://www.plantbreedbio.org/journal/view.html?doi=10.9787/PBB.2017.5.4.314.

16.  Byrne P. 2023. Fava Bean (Vicia fava). In: Chen K, Byrne P (Eds.) Understudied Indigenous Crops. Fort Collins, Colorado: Colorado State University. Date accessed. Available from https://colostate.pressbooks.pub/understudiedindigenouscrops/chapter/fava-bean/.

17.  Alfaro D.2024, What Are Fava Beans. Available from: https://specialtyproduce.com/produce/Fava_Beans_608.php.

18.  Tesoro C , Lelario F, Piscitelli F, Capua ED, Sala PD, Montoro P, Bianco G, Acquavia MA,Dell’Agli M, et, al. 2024, Vicia  fava L. Pod Valves: A By-Product with High Potential as an Adjuvant in the Treatment of Parkinson’s Disease, Available from: https://www.mdpi.com/1420-3049/29/16/3943.

19.  Hill A, 2023. 10 Impressive Health Benefits of Fava Bean. Healthline, Updated on December 6, 2018, last reviewed on 2023. Available from: https://www.healthline.com/nutrition/fava-beans.

20.  Pasqualone A, Abdallah A & Summo C. 2020, Symbolic meaning and use of broad beans in traditional foods of the Mediterranean Basin and the Middle East. Journal of Ethnic Foods: 7(39). Available from: https://journalofethnicfoods.biomedcentral.com/articles/10.1186/s42779-020-00073-1.

21.  CôtéDM, Achouri A, Karboune K, Hocine LL. 2022, Fava Bean: An Untapped Source of Quality Plant Proteins and Bioactives. Nutrients, 7;14 (8):1541.Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9025908/.

22.  Dhull SB, Kidwai MK, Noor K, Chawla P, Rose PK. 2021. A review of nutritional profile and processing of Fava bean (Vicia fava L.). Legume Science; 4(3):e129. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/leg3.129.

23.  Nutrition Facts. University of Rochester Medical Centre. Available from: https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=76&contentid=43528-.

24.  Fenga Z, Mortona JD, Maes E, Kumar L & Serventic L. 2024, Exploring Fava beans (Vicia fava L.): bioactive compounds, cardiovascular health, and processing insights Exploring. Tandofonline, Available from: https://doi.org/10.1080/10408398.2024.2387330.

25.  Labba ICM, Frøkiær H, Sandberg AS. 2021. Nutritional and antinutritional composition of fava bean (Vicia fava L., var. minor) cultivars. Food Research International, 140. Available from:https://www.sciencedirect.com/science/article/pii/S0963996920310632.

26.  Randy W. Purves, Haixia Zhang, Hamid Khazaei, Albert Vandenberg, “Rapid analysis of medically relevant compounds in Fava bean seeds using FAIMS and mass spectrometry”, Published online: 9 November 2017 https://doi.org/10.100712127-017-0226-7.

27.  Masendra, Irawati D, Shoolichah A, Ridlo S, Lukmandaru G. 2020, Phenol Contents and Antioxidant Activity of Sonokeling (DalbergialatifoliaRoxb) Wood. Wood Research Journal, DOI: 10.51850/wrj.2020.11.1.27-34. Available from: http://www.ejournalmapeki.org/index.php/wrj/article/view/472

28.  Raguthu L, Varanese S, Flancbaum F, Tayler E, Di Rocco A. 2009, Fava beans and Parkinson’s disease: useful ‘natural supplement’ or useless risk?, European Journal of Neurology; 16(10) :e171-e171.Availablefrom:https://onlinelibrary.wiley.com/doi/10.1111/j.1468-1331.2009.02766.x.

29.  Ain S, Ain Q, Chaturvedi S,  Kumar B. Comparative assessment of groundwater quality in different areas of Delhi NCR (Ghaziabad, Noida) and East UP (Varanasi). 2021, IJPP; 8 (1): 58-64.

30.  Ain S, Ain Q, Pandey S, Tyagi V, Vats Y, Ruhela N and Kumar B. Assessment of ground water quality in different areas of Uttar Pradesh and Haryana. 2025, Cuestiones de Fisioterapia; 54 (2), 3557-3575.

31.  Dhama PK, Ain S, Kumar B and Ain Q. Development and evaluation of topical ointment formulation containing gallic acid as an active pharmaceutical ingredient against bacterial infection and oxidative damage. 2025, Annals of Phytomedicine ; 11(11): 439-449, 2022.

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