ABSTRACT:
Can natural extracts from papaya leaves be effectively formulated into a herbal gel for potential dermal applications? This study explores the development and characterization of a papaya (Carica papaya) leaf-based gel using ethanolic extraction and Carbopol 934 as a gelling agent. Fresh papaya leaves were extracted using ethanol through maceration to isolate bioactive components. Phytochemical screening of the extract, conducted via UV spectrophotometry and FTIR spectroscopy, revealed the presence of glycosides, tannins, flavonoids, and saponins—compounds known for their potential therapeutic benefits. The herbal gel was formulated using Carbopol 934 and isopropyl alcohol as a penetration enhancer. The formulation demonstrated a pH of 6, suitable for topical application. Its swelling index was measured at 220%, higher than the 190% observed in the blank gel, suggesting enhanced hydration properties. Spreadability tests showed a spot diameter ranging from 3.5 to 3.7 cm, indicating good application characteristics. FTIR analysis confirmed no adverse interactions between the phytochemicals and excipients. These findings support the potential of papaya leaf extract in the formulation of effective and stable herbal gels for dermal use, highlighting its promise in natural skincare or therapeutic preparations.
Cite this article:
Nikhil Ashok Chaudhari* , Pavan Manrang Chaudhari , Madhuri Machindra Bhutekar, Vaibhav Sunil Borse. Formulation and Characterisation of Papaya Leaf Gel. IJRPAS, April 2025; 4 (4): 140-145.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4415
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