ABSTRACT:
In silico screening is a natural progression of molecular docking or database searching based on three-dimensional pharmacophores. able to assess big compound databases automatically. The results of previous researches point to a few heterocyclic molecules as possible scaffolds. Thiadiazolidine, suggested as a promising scaffold as anti-diabetic drug, was discovered thanks to virtual screening. Two thiazolidine derivatives were synthesized for this study after being screened for synthetic feasibility, their docking scores were examined, their physical characteristics were described, and invitro antidiabetic efficacy was discovered By inhibiting the alpha amylase enzyme, the antidiabetic effect was carried out. The response was observed at 540 nm .Despite the fact that compounds TD1 and TD2 had docking scores of -8.4 and -8.2, respectively, the in vitro investigation demonstrated that compound TD1 had greater inhibitory potential. Thiazolidine derivatives are a more promising scaffold in the line of antidiabetic medicines, according to this study, as the synthesized compounds nearly matched the invitro alpha amylase inhibition potential. Conducting in vivo investigations would provide a clearer understanding of what makes this antidiabetic drug distinct.
Cite this article:
Dr. Sundhararajan, Silpa N*, Jeevitha J, Jayashree KR, Jameerul Hasan S. In silico design, synthesis and in-vitro evaluation of thiazolidine derivatives. IJRPAS, March 2025; 4 (3): 50-56.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4307
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