ABSTRACT:
The assessed the safety, tolerability, and efficacy of the tablet formulation of meloxicam (10 mg), a new, nonsteroidal anti-inflammatory drug (NSAID), in patients with confirmed osteoarthritis (OA) of the hip or knee. Poor water solubility and a slow dissolution rate are problems for the majority of new and existing biologically active compounds, solubility was improved in this work in a novel way. Through the use of Nanocrystal technology, the current study aimed to improve the oral bioavailability of the drug Meloxicam, a poorly water soluble drug, by speeding up its rate of dissolution. In the present work Nanocrystal is made by nanoprecipitation technique in the presence of Sodium lauryl sulfate as a surfactant, Poloxamer 188 as a wetting agent and HPMC E-50 as a stabilizer and PVP K-30. Particle size, DSC, FTIR, XRD, SEM and Redispersibility study were used to analyse and characterize the prepared Nanocrystal. FTIR spectrum revealed that there are no interactions between drug and carriers. Drug content, entrapment effectiveness and in-vitro dissolution were all assessed for the formulations. SEM results showed the particle size of the formulated Nanocrystal in nanosize. Finally it was concluded that formulating poorly soluble drugs in the form of Nanocrystal would be a promising approach in delivery of poor water soluble drugs by oral route in a simple and effective way. It optimized Nanocrystal formulation containing Meloxicam showed higher in vitro drug release, as compared to marketed formulation. The stability study of Nanocrystal has shown suitable results. It revolves that there’s no change in drug content, redispersibility study and particle size.
Cite this article:
Anuja P. Patil, Harshal D. Mahajan, Tanvirahmad J. Shaikh, Vinod S. Ahire Rajendra D. Wagh. Formulation and In-Vitro Characterization of Oral Nanocrystals of Meloxicam. IJRPAS, November 2025; 4(11): 80-90.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.41108
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