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Author(s): Shreyash Tripathi *1, Dr. Sanjay Bhawar2

Email(s): 1shrshtripathi827@gmail.com

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    1. PhD Scholar, Faculty of Pharmacy (Pharmacology) Bhagwant University, Ajmer (Rajasthan), India 2. Dr. Sanjay Bhawar, Professor,Bhagwant University, Ajmer (Rajasthan), India

Published In:   Volume - 4,      Issue - 11,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.41105  

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ABSTRACT:
This comprehensive study investigates the pharmacological properties of Daucus carota (carrot), with particular emphasis on its potent antioxidant activity and hepatoprotective effects. Daucus carota represents a valuable medicinal plant species that has garnered significant attention in contemporary phytopharmacological research due to its rich phytochemical composition and therapeutic potential. The present investigation focuses on elucidating the mechanisms through which carrot extracts exert their biological activities, particularly in combating oxidative stress and protecting hepatic tissue from chemical-induced damage. The phytochemical analysis revealed that Daucus carota contains an impressive array of bioactive compounds that contribute to its therapeutic efficacy. Key constituents identified include phenolic compounds such as chlorogenic acid and trans-ferulic acid, which serve as primary antioxidant agents Both in vitro and in vivo experimental evidence substantiates the robust antioxidant mechanisms of Daucus carota. Cell-based assays demonstrated significant free radical scavenging capacity, while animal model studies revealed protective effects against oxidative stress-induced hepatotoxicity. Given the rising incidence of liver diseases globally and the limitations of conventional synthetic drugs, natural hepatoprotective agents like Daucus carota offer promising therapeutic alternatives. The findings suggest potential applications in developing functional foods, nutraceutical formulations, and complementary therapeutic interventions for managing oxidative stress-related hepatic disorders. This study contributes valuable insights into the pharmacological validation of traditional medicinal uses of carrot and establishes a scientific foundation for its integration into evidence-based complementary medicine practices.

Cite this article:
Shreyash Tripathi, Dr. Sanjay Bhawar. Pharmacological Evaluation of Daucus carota for its Hepatoprotective and Antioxidant Activity. IJRPAS, November 2025; 4(11): 45-59DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.41105


1.      Ismail, S.M., Mohamed, A.A., s Hassan, R.A. (2023). Pharmacological properties and therapeutic potential of Daucus carota (wild carrot): A comprehensive review. Nutrients, 15(8), 1882.

2.      Deshmukh, P.B., Kale, R.N., s Deshpande, N.R. (2021). Pharmacological review on Daucus carota (carrot): A valuable medicinal plant. International Journal of Pharmacy and Pharmaceutical Research, 22(3), 456-478.

3.      Hadji, M., Boulaaba, M., s Brahmi, F. (2024). Phenolic profiling and antioxidant evaluation of Daucus carota subspecies: Comparative analysis of wild and cultivated varieties. Journal of Food Biochemistry, 48(2), e14521. https://doi.org/10.1111/jfbc.14521

4.      Singh, A., Kumar, S., s Sharma, R. (2025). Comparative antioxidant activity studies of colored carrot varieties: Purple, black, and orange cultivars. Food Chemistry, 412, 135847.

5.      Montilla, E.C., Arzaba, M.R., Hillebrand, S., s Winterhalter, P. (2011). Anthocyanin composition of black carrot (Daucus carota ssp. sativus var. atrorubens Alef.) cultivars Antonina, Beta Sweet, Deep Purple, and Purple Haze. Journal of Agricultural and Food Chemistry, 59(7), 3385-3390.

6.      6.Alasalvar, C., Grigor, J.M., Zhang, D., Quantick, P.C., s Shahidi, F. (2001). Comparison of volatiles, phenolics, sugars, antioxidant vitamins, and sensory quality of different colored carrot varieties. Journal of Agricultural and Food Chemistry, 49(3), 1410-1416.

7.      da Silva Dias, J.C. (2014). Nutritional and health benefits of carrots and their seed extracts. Food and Nutrition Sciences, 5(22), 2147-2156.

8.      Zidorn, C., Jöhrer, K., Ganzera, M., Schubert, B., Sigmund, E.M., Mader, J., Greil, R., Ellmerer, E.P., s Stuppner, H. (2005). Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities. Journal of Agricultural and Food Chemistry, 53(7), 2518- 2523.

9.      Sharma, K.D., Karki, S., Thakur, N.S., s Attri, S. (2012). Chemical composition, functional properties and processing of carrot4A review. Journal of Food Science and Technology, 49(1), 22-32.

10.  Ahmad, T., Cawood, M., Iqbal, Q., Ariño, A., Batool, A., Tariq, R.M.S., Azam, M., s Akhtar, S. (2019). Phytochemicals in Daucus carota and their health benefits4Review article. Foods, 8(9), 424.

11.  Leja, M., Kamińska, I., Kramer, M., Maksylewicz-Kaul, A., Kammerer, D., Carle, R., s Baranski, R. (2013). The content of phenolic compounds and radical scavenging activity varies with carrot origin and root color. Plant Foods for Human Nutrition, 68(2), 163-170.

12.  Sun, T., Simon, P.W., s Tanumihardjo, S.A. (2009). Antioxidant phytochemicals and antioxidant capacity of biofortified carrots (Daucus carota L.) of various colors. Journal of Aricultural and Food Chemistry, 57(10), 4142-4147.

13.  Strati, I.F., s Oreopoulou, V. (2011). Effect of extraction parameters on the carotenoid recovery from tomato waste. International Journal of Food Science & Technology, 46(1), 23-29.

14.  Ozoğul, Y., Polat, A., s Özogul, F. (2004). The effects of modified atmosphere packaging and vacuum packaging on chemical, sensory and microbiological changes of sardines (Sardina pilchardus). Food Chemistry, 85(1), 49-57.

15.  Arscott, S.A., s Tanumihardjo, S.A. (2010). Carrots of many colors provide basic nutrition and bioavailable phytochemicals acting as a functional food. Comprehensive Reviews in Food Science and Food Safety, 9(2), 223-239.

16.  Baranski, R., Allender, C., s Klimek-Chodacka, M. (2012). Towards better tasting and more nutritious carrots: Carotenoid and sugar content variation in carrot genetic resources. Food Research International, 47(2), 182-187.

17.  Grassmann, J., Hippeli, S., s Elstner, E.F. (2002). Plant's defence and its benefits for animals and medicine: Role of phenolics and terpenoids in avoiding oxygen stress. Plant Physiology and Biochemistry, 40(6-8), 471-478.

18.  Nicolle, C., Simon, G., Rock, E., Amouroux, P., s Rémésy, C. (2004). Genetic variability influences carotenoid, vitamin, phenolic, and mineral content in white, yellow, purple, orange, and dark-orange carrot cultivars. Journal of the American Society for Horticultural Science, 129(4), 523-529.

19.  Surles, R.L., Weng, N., Simon, P.W., s Tanumihardjo, S.A. (2004). Carotenoid profiles and consumer sensory evaluation of specialty carrots (Daucus carota, L.) of various colors. Journal of Agricultural and Food Chemistry, 52(11), 3417-3421.

20.  Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M., s Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry & Cell Biology, 39(1), 44-84.

21.  Wellington, K., s Jarvis, B. (2001). Silymarin: A review of its clinical properties in the management of hepatic disorders. BioDrugs, 15(7), 465-489.

22.  Young, J.F., Christensen, L.P., Theil, P.K., s Oksbjerg, N. (2008). The polyacetylenes falcarinol and falcarindiol affect stress responses in myotube cultures in a biphasic manner. Dose-Response, 6(3), 239-251.

23.  Zhang, D., s Hamauzu, Y. (2004). Phenolics, ascorbic acid, carotenoids and antioxidant activity of broccoli and their changes during conventional and microwave cooking. Food Chemistry, 88(4), 503-509.

24.  Kris-Etherton, P.M., Hecker, K.D., Bonanome, A., Coval, S.M., Binkoski, A.E., Hilpert, K.F., Griel, A.E., s Etherton, T.D. (2002). Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer. The American Journal of Medicine, 113(9), 71-88.

25.  Gupta, V.K., s Sharma, S.K. (2006). Plants as natural antioxidants. Natural Product Radiance, 5(4), 326-334.

 

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