International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

Abstract View

Correlation of Central Corneal Thickness (CCT) and Intraocular Pressure (IOP) in Myopes and Hyperopes

Author(s): Dr. Orji Emele1, Favour Nkasiobi*2, Dr. Azuamah Young Christian3, Dr. Daniel Nwosu4, Edith5, Prof. Ikoro Nwakaego6, Dr. Nkemka7, Victoria Ezinne8

Email(s): 1favouremeleorji25@gmail.com

Address:

    Department of Optometry, Federal University of Technology, Owerri, Nigeria

Published In:   Volume - 4,      Issue - 11,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.41103  

 View HTML        View PDF

Please allow Pop-Up for this website to view PDF file.

ABSTRACT:
Central corneal thickness (CCT) and intraocular pressure (IOP) are two essential parameters in ocular assessment, both of which can be influenced by refractive status. Understanding their correlation across different refractive error types is critical for accurate diagnosis and management of ocular conditions. This study aimed to evaluate the correlation between CCT and IOP among individuals with myopia and hyperopia, using emmetropic eyes as the control group. A comparative cross-sectional observational study was conducted at the Police Hospital, Abuja, Nigeria, from January to April 2025. A total of 78 participants aged 18–70 years were included, comprising 37 myopes and 41 hyperopes. An additional 35 randomly selected emmetropic eyes served as the control group. CCT was measured using the SUOER SW-1000 AP pachymeter, and IOP was measured with the Reichert AT550 tonometer. Data analysis was performed using IBM SPSS version 25, with correlation analysis used to determine relationships between CCT and IOP. A statistically significant positive correlation was found between CCT and IOP in myopic eyes (r = 0.349, p = 0.037), while hyperopic eyes showed a weak and statistically non-significant correlation (r = 0.209, p = 0.190). Emmetropic group, presented a non-significant correlation (r = 0.157), (p = 0.376). The findings suggest that central corneal thickness has a significant influence on IOP in myopic individuals but not in hyperopic or emmetropic eyes. These results underscore the importance of considering CCT when interpreting IOP, especially in patients with myopia, to avoid misdiagnosis of ocular conditions.

Keywords:

Cite this article:
Dr. Orji Emele, Favour Nkasiobi*, Dr. Azuamah Young Christian, Dr. Daniel Nwosu, Edith, Prof. Ikoro Nwakaego, Dr. Nkemka, Victoria Ezinne. Correlation of Central Corneal Thickness (CCT) and Intraocular Pressure (IOP) in Myopes and Hyperopes. IJRPAS, November 2025; 4(11): 23-33.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.41103


  1. Oladigbolu, Kehinde; Abdullahi, Hauwa; Abdulsalam, Halima; Gana, Olutayo; Kadala, Nachafiya; Pam, Victoria. Central corneal thickness measurement of non-glaucomatous adults in Ahmadu Bello University Sick Bay, Samaru, Zaria. Sub-Saharan African Journal of Medicine. 2018: 5(3): p 69-73. doi: 10.4103/ssajm.ssajm_30_18
  2. Kadhim YJ, Farhood QK. Central corneal thickness of Iraqi population in relation to age, gender, refractive errors, and corneal curvature: a hospital-based cross-sectional study. Clin Ophthalmol. 2016; 10:2369-2376. doi.org/10.2147/OPTH.S116743
  3. Wei, W., Fan, Zh., Wang, L., Li, Zh., Jiao, W. and Li, Y. Correlation Analysis between Central Corneal Thickness and Intraocula Pressure in Juveniles in Northern China. PLoS ONE. 2014: 9, e104842. doi.org/10.1371/journal.pone.0104842
  5. Mashige, K.P. A Review of Corneal Diameter, Curvature and Thickness Values and Influencing Factors. South African Optometrist. 2013: 72, 185-194. doi.org/10.4102/aveh.v72i4.58
  6. Patwardhan, A.A., Khan, M., Mollan, S.P. and Haigh, P. (2008) The Importance of Central Corneal Thickness Measurements and Decision Making in General Ophthalmology Clinics: A Masked Observational Study. BMC Ophthalmology. 2008: 8, 1. doi.org/10.1186/1471-2415-8-1
  7. Sawada, A., Tomidokoro, A., Araie, M., Iwase, A. and Yamato, T. Refractive Errors in an Elderly Japanese Population: The Tajimi Study. Ophthalmology. 2008: 115, 363-370. doi.org/10.1016/j.ophtha.2007.03.075 
  8. Ismaili, M., Kaçaniku, G., Spahiu, K. , Hoxha, G. , Наќева-Јаневска, Н. and Димовска-Јорданова, В. Determination of Central Corneal Thickness in Patients with Refractive Anomalies and Emmetropy. Open Journal of Ophthalmology.2019: 9, 35-46. doi: 10.4236/ojoph.2019.92005
  9. Mohamed Ismail, M., El-Din Abd Al-Hamid Abd Al-Halim, N., Abd Allah Mahmoud El-Sheikh, A. correlation between central corneal thickness and degree of hyperopia. Al-Azhar Medical Journal, 2019; 48(4): 525-550. doi: 10.21608/amj.2019.64958
  10. Osaiyuwu AB, Edokpa GD. A comparative study of intraocular pressure in myopia and hyperopia among a Nigerian population just diagnosed with primary open angle glaucoma in Benin City. Int J Res Med Sci, 2018; 6(7):2234-7. doi.org/10.18203/2320-6012.ijrms20182457
  11. Sharma N., Singhvi A., Sinha R., Vajpayee R.B. Reasons for not performing LASIK in refractive surgery candidates. J Refract Surg. 2005; 21:496–498. doi: 10.3928/1081-597X-20050901-13.
  12. Mangouritsas G., Mourtzoukos S., Mantzounis A., Alexopoulos L. Comparison of Goldmann and Pascal tonometry in relation to corneal hysteresis and central corneal thickness in non-glaucomatous eyes. Clin Ophthalmol. 2011; 5:1071–1077. doi: 10.2147/OPTH.S23086.
  13. Kunert K.S., Bhartiya P., Tandon R., Dada T., Christian H., Vajpayee R.B. Central corneal thickness in Indian patients undergoing LASIK for myopia. J Refract Surg. 2003; 19:378–379. doi: 10.3928/1081-597X-20030501-18.
  14. Hosny M., Alio J.L., Claramonte P., Attia W.H., Perez-Santonja J.J. Relationship between anterior chamber depth, refractive state, corneal diameter, and axial length. J Refract Surg. 2000; 16:336–340. doi: 10.3928/1081-597X-20000501-07.
  15. AlMahmoud T., Priest D., Munger R., Jackson W.B. Correlation between refractive error, corneal power, and thickness in a large population with a wide range of ametropia. Invest Ophthalmol Vis Sci. 2011; 52:1235–1242. doi: 10.1167/iovs.10-5449.
  16. Chen M.J., Liu Y.T., Tsai C.C., Chen Y.C., Chou C.K., Lee S.M. Relationship between central corneal thickness, refractive error, corneal curvature, anterior chamber depth and axial length. J Chin Med Assoc. 2009; 72:133–137. doi: 10.1016/S1726-4901(09)70038-3.
  17. Al-Mezaine H.S., Al-Obeidan S., Kangave D., Sadaawy A., Wehaib T.A., Al-Amro The relationship between central corneal thickness and degree of myopia among Saudi adults. Int Ophthalmol. 2009; 29:373–378. doi: 10.1007/s10792-008-9249-8.
  18. De Medeiros F.W., Sinha-Roy A., Alves M.R., Wilson S.E., Dupps W.J., Jr. Differences in the early biomechanical effects of hyperopic and myopic laser in situ keratomileusis. J Cataract Refract Surg. 2010; 36:947–953. doi: 10.1016/j.jcrs.2009.12.032.
  19. Gros-Otero J., Arruabarrena-Sánchez C., Teus M. Central corneal thickness in a healthy Spanish population. Arch Soc Esp Oftalmol. 2011; 86:73–76. doi: 10.1016/j.oftal.2010.12.008.
  20. Suzuki S, Suzuki Y, Iwase A, Araie M. Corneal thickness in an ophthalmologically normal Japanese population. Ophthalmology. 2005 Aug;112(8):1327-36. doi: 10.1016/j.ophtha.2005.03.022
  21. Nomura, H., Ando, F., Niino, N., Shimokata, H. and Miyake, Y. The Relationship between Age and Intraocular Pressure in a Japanese Population: The Influence of Central Corneal Thickness. Current Eye Research. 2002: 24, 81-85. doi.org/10.1076/ceyr.24.2.81.8161
  22. Al Mahmoud, T., Priest, D., Munger, R. and Jackson, B. Correlation between Refractive Error, Corneal Power, and Thickness in a Large Population with a Wide Range of Ametropia. Investigative Ophthalmology & Visual Science. 2011: 52, 1235-1242. doi.org/10.1167/iovs.10-5449 
  23. Chang SW, Tsai IL, Hu FR, Lin LL, Shih YF. The cornea in young myopic adults. Br J Ophthalmol. 2001 Aug;85(8):916-20. doi: 10.1136/bjo.85.8.916
  24. Liu, Z. and Pflugfelder, S.C. The Effects of Long-Term Contact Lens Wear on Corneal Thickness, Curvature, and Surface Regularity. American Academy of Ophthalmology. 2000: 107, 105-111. doi.org/10.1016/S0161-6420(99)00027-5
  25. Bradfield, Y.S., Melia, B.M., Repka, M.X., Kaminski, B.M., Davitt, B.V. Central Corneal Thickness in Children. Archives of Ophthalmology. 2011: 129, 1132-1138. doi.org/10.1016/j.jaapos.2011.01.011
  26. Mimouni, M., Flores, V., Shapira, Y., Graff, Sh., Levartovsky, Sh., Sela, T., Munzer, G. and Kaiserman, I. Correlation between Central Corneal Thickness and Myopia. International Ophthalmology.2018: 38, 2547-2551. doi.org/10.1007/s10792-017-0766-1

 

Related Images:



Recent Images



Neurological Complications among Pregnant and Post Partum Mothers in a Private Hospital, Yogyakarta, Indonesia
Review on Regulatory Affairs in Pharmaceutical Industry
Cucumber and Mint Soap: Preparation and Evaluation
Topical Delivery in Cosmetics: Enhancing Penetration and Bioavailability
Formulation and Evaluation of Polyherbal Soap
Gelatin: A Widely Used Pharmaceutical Excipient
Therapeutic insights into Saroglitazar: a dual PPAR- α/γ agonist targeting diabetic dyslipidaemia and NAFLD
A Comprehensive Review on Dyslipidemia and Obesity: Pathophysiology, Clinical Implications and Management Approaches
Antidiabetic Herbs and Polyherbal Antidiabetic Formulations –An Overview
Review on Clinical Research and Clinical Trials

Tags


Quick Links


Latest Issues

Popular Articles