ABSTRACT:
Peptic ulcer disease (PUD) is a chronic gastrointestinal ailment caused by an imbalance between aggressive forces, including stomach acid, pepsin, Helicobacter pylori infection, and NSAID use, as well as defensive mechanisms like mucus, bicarbonate, prostaglandins, and antioxidants. Although they relieve symptoms, conventional therapies, including proton pump inhibitors and H2 receptor antagonists, are frequently related to side effects, drug resistance, and high relapse rates.
Using specific medicinal plants that have been shown to have anti-ulcer, antioxidant, and cytoprotective qualities, herbal formulations were created and described in this study as possible substitutes or supplements to conventional treatment. Bioactive components including flavonoids, tannins, and saponins, were detected by phytochemical screening. In vitro antioxidant tests and in vivo ulcer induction models were used to produce and assess polyherbal formulations.
The results demonstrated significant gastroprotective activity, including reduction in gastric volume and ulcer index, enhancement of mucosal defense, and restoration of endogenous antioxidant enzyme levels. Histopathological observations further confirmed reduced mucosal damage and improved epithelial regeneration, while some formulations also exhibited inhibitory activity against H. pylori. Overall, the findings suggest that herbal formulations exert synergistic gastroprotective effects through anti-secretory, cytoprotective, antioxidant, and antimicrobial mechanisms.
These findings demonstrate the promise of herbal remedies as secure, reasonably priced, and successful means of managing and preventing peptic ulcer disease; nevertheless, more standardization, toxicity assessment, and clinical validation are necessary prior to therapeutic use. Keywords: gastroprotection, phytoconstituents, antioxidants, cytoprotection, peptic ulcer, herbal formulations
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