ABSTRACT:
Oral drug delivery remains pivotal in pharmaceutical practice due to its convenience, patient compliance, and cost-effectiveness. However, a significant proportion of drugs suffer from poor water solubility, which limits their bioavailability and therapeutic efficacy. This review examines various solubility enhancement strategies aimed at overcoming these challenges in oral drug delivery. Techniques discussed include physical modifications (e.g., particle size reduction, crystal engineering), chemical modifications (e.g., salt formation, pro-drug synthesis), and advanced nanotechnology-based approaches (e.g., Nano sponges, nanocrystals). Solid dispersion technology emerges as a promising strategy to enhance solubility by dispersing drug molecules in inert matrices. The advantages and disadvantages of each technique are critically analysed, emphasizing their applications in improving drug absorption and bioavailability. Challenges such as formulation complexity, stability issues, and regulatory considerations are also discussed. By providing a comprehensive overview, this review aims to guide researchers and pharmaceutical developers in selecting appropriate solubility enhancement strategies to address the persistent challenges of poorly water-soluble drugs in oral drug delivery, thereby improving therapeutic outcomes and patient care.
Cite this article:
Shaikh Aminoddin Raisoddin, Shifa Maniyar, Sayeeda Begum, Naziya Shaikh. Solubility Enhancement of Nevirapine by Solid Dispersion Technique. IJRPAS, May-June 2024; 3(3): 01-09. 2013-2019
1.
Modi Kushai, Modi Monali,
Mishra Durgavati, Panchal Mittal, Et Al. Oral Controlled Release Drug Delivery
System: An Overview. International Research Journal Of Pharmacy. 2013;
4(3):70-75.
2.
Anand, O., Lawrence, X.Y.,
Conner, D.P. And Davit, B.M. Dissolution Testing For Generic Drugs: An Fda
Perspective. The Aaps Journal. 2011; 13(3): 328.
3.
Kansara, H., Panola, R. And
Mishra, A. Techniques Used To Enhance Bioavailability Of Bcs Class Ii Drugs: A
Review. International Journal Of Drug Development And Research. 2015; 7(1):
82-93.
4.
Patel, J.N., Rathod, D.M.,
Patel, N.A. And Modasiya, M.K, Et Al. Techniques To Improve The Solubility Of
Poorly Soluble Drugs. International Journal Of Pharmacy & Life Sciences.
2012; 3(2):1459-1469.
5.
Humberstone, A.J. And Charman,
W.N. Lipid-Based Vehicles For The Oral Delivery Of Poorly Water Soluble Drugs.
Advanced Drug Delivery Reviews. 1997; 25(1): 103-128
6.
Sandeep Kalepu, Vijaykumar
Nekkanti. Insoluble Drug Delivery Strategies: Review Of Recent Advances And
Business Prospects. Acta Pharmaceutica Sinica B. 2015; 5(5): 442-453.
7.
Nayaz, A., Thakur, R.S. And
Koushik, Y. Formulation And Evaluation Of Solubility Enhanced Ciprofloxacin.
International Journal Of Pharmaceutical Sciences And Nanotechnology.2013; 6(3):
2131-2136.
8.
Kishor. S. Rathi, Sapana
Ahirrao, Sanjay Kshirsagar. Review Article: Solubility Enhancement By Solid
Dispersion. Indian Journal Of Drugs. 2018; 6(3): 165-173.
9.
Nikhil K Sachan, A.
Bhattacharya, Seema Pushkar, A Mishra. Biopharmaceutical Classification System:
A Strategic Tool For Oral Drug Delivery Technology. Asian Journal Of
Pharmaceutics. 2009; 2009:76-80.
10. Kataria Mahesh Kumar, Bhandari Anil. Biopharmaceutics Drug
Disposition Classification System: An Extension Of Biopharmaceutics
Classification System. International Journal Of Pharmacy.2012; 3(3): 5-10.
11. Vilas P Bharti, Vinayta R Attal, Anirudha V Munde, Arunadevi S
Birajdar. Strategies To Enhance Solubility And Dissolution Of A Poorly Water
Soluble Drug. Journal Of Innovations In Pharmaceuticals And Biological
Sciences. 2015; 2 (4): 482-494.
12. Phuong Tran, Yong-Chul Pyo, Dong-Hyun Kim, Sang-Eun Lee Et Al.
Overview Of The Manufacturing Methods Of Solid Dispersion Technology For
Improving The Solubility Of Poorly Water-Soluble Drugs And Application To
Anticancer Drugs. Pharmaceutics. 2019; 11(132):1-26.