International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Advancements in Spherical Crystallization: Tailoring Drug Particles for Enhanced Properties and Bioavailability

Author(s): Aditya Sujit Rathod11, Mrs. Urmila J Patel2*.2

Email(s): 1urmilapatel.pharmacy@spec.edu.in

Address:

    1. A.R.A. college of pharmacy, Nagaon Dhule 2. Sardar Patel Education Campus Vidyanager At Bakrol Anand Gujarat 388315.

Published In:   Volume - 2,      Issue - 5,     Year - 2023

DOI: Not Available

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ABSTRACT:
Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The principle steps involved in the process of spherical crystallization are flocculation zone, zero growth zone, fast growth zone and constant size zone. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo- co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, such as temperature, stirring rate, type and amount of solvents, or excipient selection, it is possible to control the formation of agglomerates and obtain spherical particles of the desired size, porosity, or hardness. Researchers have reported that the particles produced have improved micromeritic, physical, and mechanical properties, which make them suitable for direct compression. In some cases, when additional excipients are incorporated during spherical crystallization, biopharmaceutical parameters including the bioavailability of drugs can also be tailored.

Keywords:

Cite this article:
Aditya Sujit Rathod, Mrs. Urmila J Patel. Advancements in Spherical Crystallization: Tailoring Drug Particles for Enhanced Properties and Bioavailability. IJRPAS, Sep-Oct 2023; 2(5): 130-142.


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