International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

Abstract View

Advancements in Spherical Crystallization: Tailoring Drug Particles for Enhanced Properties and Bioavailability

Author(s): Aditya Sujit Rathod11, Mrs. Urmila J Patel2*.2

Email(s): 1urmilapatel.pharmacy@spec.edu.in

Address:

    1. A.R.A. college of pharmacy, Nagaon Dhule 2. Sardar Patel Education Campus Vidyanager At Bakrol Anand Gujarat 388315.

Published In:   Volume - 2,      Issue - 5,     Year - 2023

DOI: Not Available

 View HTML        View PDF

Please allow Pop-Up for this website to view PDF file.

ABSTRACT:
Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The principle steps involved in the process of spherical crystallization are flocculation zone, zero growth zone, fast growth zone and constant size zone. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo- co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, such as temperature, stirring rate, type and amount of solvents, or excipient selection, it is possible to control the formation of agglomerates and obtain spherical particles of the desired size, porosity, or hardness. Researchers have reported that the particles produced have improved micromeritic, physical, and mechanical properties, which make them suitable for direct compression. In some cases, when additional excipients are incorporated during spherical crystallization, biopharmaceutical parameters including the bioavailability of drugs can also be tailored.

Keywords:

Cite this article:
Aditya Sujit Rathod, Mrs. Urmila J Patel. Advancements in Spherical Crystallization: Tailoring Drug Particles for Enhanced Properties and Bioavailability. IJRPAS, Sep-Oct 2023; 2(5): 130-142.


1.      Paradkar AR, Pawar AP, Mahadik KR, Kadam SS. Spherical crystallization: a novel particle design technique. Indian Drugs. 1994;6:229–233.

2.      Kawashima Y. Spherical crystallization as a novel particle design technique for oral drug delivery system. Chin Pharm J. 1989;41:163-172.

3.      Chouracia MK, Jain A, Valdya S, Jain SK. Indian Drugs. 2004;41(6):319-329.

4.      Bose AJ, Heerens JJ. Chem Eng Commun. 1982;16(3):301-311.

5.      Maryam M. Advanced Pharmaceutical Bulletin. 2012;2(2):253-257.

6.      Gupta MM, Srivastava B, Sharma M, Arya V. Spherical crystallization: a tool of particle engineering for making drug powder suitable for direct compression. Int J Pharm Res Dev. 2010;12:1-10.

7.      Bharti N, Bhandari N, Sharma P, Singh K, Kumar A. Asian J Biomed Pharm Sci. 2013;18(3):10-16.

8.      Chouracia MK, Jain A, Valdya S, Jain SK. Utilization of spherical crystallization for preparation of directly compressible materials. Indian Drugs. 2004;41(6):319-329.

9.      Yadav VB, Yadav AV. Trop J Pharm Res. 2009;8(4):361-369.

10.  Nokhodchi A, Maghsoodi M, Hassanzadeh D. Iran J Pharm Res. 2007;6(2):83-93.

11.  Dixit M, Kulkarni PK, Bose PSC, Reddy R. Int J Pharm Res Dev. 2010;2(9):33-43.

12.  Jyothi K, Rasmuson AC. Spherical crystallization of benzoic acid. Int J Pharm. 2008;348:61-69.

13.  Ueda M, Nakamura Y, Makita H, Imasato Y, Kawashima Y. Chem Pharm Bull. 1990;38(9):2537-2541.

14.  Sano A, Kuriki T, Kawashima Y, Takeuchi H, Hino T, Niwa T. Particle design of Tolbutamide by the spherical crystallization technique IV, Improved of dissolution and bioavailability of direct compression tablets prepared using Tolbutamide agglomerated crystals. Chem Pharm Bull. 1992;40:3030-3035.

15.  Yadav AV, Yadav VB. Designing of pharmaceuticals to improve physicochemical properties by spherical crystallization technique. J Pharm Res. 2008;1(2):105-110.

16.  Chouracia MK, Jain A, Valdya S, Jain SK. Indian Drugs. 2004;41(6):319-329.

17.  Gupta MM, Srivastava B, Sharma M, Arya V. Int J Pharm Res Dev. 2010;12(2):1-10.

18.  Bharti N, Bhandari N, Sharma P, Singh K, Kumar A. Asian J Biomed Pharm Sci. 2013;18(3):10-16.

19.  Yadav VB, Yadav AV. Trop J Pharm Res. 2009;8(4):361-369.

20.  Thati J. Particle Engineering By Spherical Crystallization: Mechanisms And Influence of Process Conditions. 2011;4(2):3-8.

21.  Di Martino P, Di Cristofaro R, Barthelemy C, Joiris E, Palmeieri FG, Sante M. Improved Compression properties, Propyphenazone spherical Crystals. 2013;3(2):4-8.

22.  Yadav AV, Yadav VB. Designing of pharmaceuticals to improve physicochemical properties by spherical crystallization technique. J Pharm Res. 2008;1(2):105-110.

23.  Goal NK, Sharma N, Sharma PK. Spherical Crystallization: A Method For Improving Powder And Tablet Characteristics. 2010;3(3):2-5.

Related Images:



Recent Images



Evaluation of In-Vitro Anti-Diabetic Activity And Antioxidant Activity In Ethanolic and Hydroalcoholic Extract of leaves of Gymnema Sylvestre
Molecular Docking Approaches in Antibacterial Drug Discovery: Computational Insights into Natural Compounds
In-vitro Evaluation of Anti-Urolithiatic Activity of Hydroalcoholic Extract of Centella asiatica Leaves
Quality by Design (Qbd) Based Method Development and Validation of Trelagliptin Succinate byu RP-HPLC.
Cubosomes: Structure, Preparation Methods, Characterization, and Pharmaceutical Applications
Programmable Oral Drug Delivery Systems: Materials, Device Engineering, Stimuli-Responsive Mechanisms, and Clinical Translation
Biomimetic Nanocarrier for Targeted Drug Delivery: An Integrated Review
From Phosphate Wasting to Targeted Therapy: An Updated Review of FGF23-Mediated Hypophosphatemic Rickets
Nanotechnology-Based Drug Delivery Systems for Alzheimer’s Disease: Emerging Strategies for Blood–Brain Barrier Targeting
Explainable AI in Pharmacy: Building Trust in AI-Based Drug Recommendation

Tags


Quick Links


Latest Issues

Popular Articles