ABSTRACT:
The phenomenon of a solid dissolving into a liquid phase to create a homogeneous system is known as solubility. To acquire the required concentration of medication in the systemic circulation for the best pharmacological response solubility is a crucial factor. The main issue in developing formulations for new chemical compounds as well as for generic development is low water solubility. About 40% of all newly discovered chemical compounds are lipophilic, which prevents their use in therapeutic doses because of their poor water solubility. Solid dispersion, solvent deposition, micronization, and complexation are a few vital techniques frequently used to improve the solubility of medications that aren't very soluble in water. Poorly water soluble in pharmaceuticals their solubility increased by the use of complexation technology. Such cyclodextrin can interact with appropriate size drug molecules which lead to the formulation of inclusion complexes. In this review, brief information about improvement of aqueous solubility of drug and improve therapeutic efficacy by inclusion complexation method. The solubility, dissolution rate, and bioavailability of poorly soluble pharmaceuticals have been reported to be improved through complexation with CDs using a variety of techniques, including physical mixing, melting, kneading, spray drying, freeze drying, and co-evaporation.